How did Goodpasture syndrome cause?

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asked in Otorhinolaryngology by GERALDINE
How did Goodpasture syndrome cause?

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answered by GEORGIA
Immunofluorescence staining showed immunoglobulin and complement deposition in the glomerular basement membrane and some patients with alveolar - capillary basement membrane.
In the lungs and kidneys, the primary target of anti-glomerular basement membrane antibodies is the non-collagen (NC-1) functional domain of the basement membrane collagen 2,3 chain. Infection, smoking and inhalation injury are thought to cause capillary damage through these antibodies, and genetic also play a role, HLA-DRW2 is associated with anti-glomerular basement membrane disease.
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