What is the reason for the high total bilirubin?

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asked in Internal Medicine by MICHELE
How is the total bilirubin high?

6 Answers

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answered by BLANCA
Liver function tests of normal people can be concerned about the health of their liver well. For hepatitis B and other liver diseases, liver function is mainly determined to determine the degree of liver injury. When liver function tests are performed, when patients have symptoms of high total bilirubin, they may be related to the development of patients' condition, but they do not exclude other reasons.
Total bilirubin includes two kinds of direct bilirubin and indirect bilirubin. Any increase in the value of bilirubin may lead to the high symptoms of the patient's total bilirubin. When the indirect bilirubin is elevated, it will lead to the occurrence of hemolytic jaundice, and the skin will appear rough, yellowing and obvious ischemia. When the patient's direct bilirubin increases, it can lead to obstructive jaundice or the appearance of cellular jaundice.
The reasons for the high total bilirubin
The causes of high total bilirubin include not only acute liver diseases such as acute jaundice hepatitis, chronic active hepatitis, but also extrahepatic diseases such as cholecystitis, cholelithiasis, hemolytic jaundice, blood transfusion incompatibility. Among them, the most common reason is the infection of hepatitis B virus, which leads to hepatocyte damage, which leads to a high level of total bilirubin. In view of this situation, antiviral therapy is urgently needed, virus clearance and liver cell injury will disappear, and total bilirubin will return to normal.
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answered by LORA
Disease analysis:
Bilirubin is a pigment made from the hemoglobin in the red cell. The red cell has a fixed life span and is destroyed every day. At this point, the hemoglobin will decompose into the heme (haem) and heme. Heme to biliverdin in the NADPH and H ions. The trivalent Fe ion and CO, generated in NADPH and bilirubin biliverdin H ions. Heme reproduces tissue protein, and bilirubin plays an important role in the metabolism of human body. The normal value of bilirubin is an important basis for determining normal / abnormal liver function.
The reasons for the high total bilirubin are:
(1): when hemolytic disease, neonatal jaundice or blood transfusion mistake, it will lead to massive destruction of red blood cells, resulting in a high level of indirect bilirubin in blood, resulting in a high level of total bilirubin.
(two) when liver and extrahepatic obstructive jaundice, pancreatic head cancer, capillary cholangio hepatitis and other biliary stasis syndrome and other diseases, biliary tract obstruction, excretion of bile damage, leading to direct bilirubin is high, resulting in high total bilirubin.
(three): when had hepatitis disease, such as acute icteric hepatitis, acute icteric hepatitis, chronic active hepatitis, liver cirrhosis, toxic hepatitis, the pathological changes of liver cells, cannot be transformed into direct bilirubin and indirect bilirubin, direct bilirubin and indirect bilirubin result are high, resulting in high total bilirubin.
Guidance:
If you drink very frequently, it's better to drink less or not. In time, further examination and definite diagnosis.
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answered by ELENA
1, total bilirubin and direct bilirubin increased: intrahepatic and extrahepatic obstructive jaundice, pancreatic head cancer, capillary bile duct hepatitis and other bile stasis syndrome.
2, total bilirubin, indirect bilirubin increased: hemolytic anemia, blood type incompatible blood transfusion, malignant disease, neonatal jaundice, and so on.
3, total bilirubin, direct bilirubin and indirect bilirubin are all increased: acute jaundice hepatitis, chronic active hepatitis, liver cirrhosis, toxic hepatitis and so on.
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answered by BETHANY
The total bilirubin is high and the indirect bilirubin is on the high side. The rest is normal. It indicates that there are a lot of damage to the red blood cells in the body, and the occurrence of hemolytic jaundice. At the same time, it may be accompanied by blood transfusion incompatibility, anemia and so on.
High total bilirubin, indirect bilirubin on the high side, high direct bilirubin, liver cell jaundice, liver damage, liver dysfunction of liver can not be transformed into direct bilirubin and indirect bilirubin, and bile duct pressure caused by the direct bilirubin excretion barriers, can not be completely discharged to the biliary tract, and may be associated with acute jaundice hepatitis, chronic active hepatitis, liver cirrhosis, liver cancer and other diseases.
The total bilirubin is high, direct bilirubin is high, other normal, indicating obstructive jaundice. The bile duct is blocked, and the bile that carries direct bilirubin can not be discharged into the body. At the same time, it may be accompanied by pancreatic head cancer, cholelithiasis, biliary malformation, bile duct cancer and other diseases.
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answered by MARYANN
Hello, bilirubin (Bilirubin) is the waste after heme metabolism of blood red blood cells in the blood. It is mainly converted from hemoglobin, and one gram of hemoglobin can produce 34mg bilirubin. Total bilirubin is unfamiliar to a lot of people. Total bilirubin is the sum of direct bilirubin and direct bilirubin two. If the bilirubin is beyond the normal range, it means that the patient may suffer from liver disease or biliary tract. At this time, it is necessary to go to the hospital for examination, confirm his condition and then follow the doctor's instructions.
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answered by DOREEN
Bilirubin is a waste after heme metabolism of red blood cells in the blood. If the total bilirubin is too high, abnormal information such as liver disease or obstruction of the bile duct is predicted. When patients are acute jaundice hepatitis, chronic active hepatitis, cirrhosis and toxic hepatitis, direct bilirubin and indirect bilirubin at the same time will lead to higher total bilirubin. In addition, when direct bilirubin is high or indirect bilirubin is high, it also causes high bilirubin. Therefore, the high risk of total bilirubin may be obstructive jaundice, cholestatic jaundice, and so on.
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