What is the cause of hyperlipidemia?

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asked in Others by SANDY
What is the cause of hyperlipidemia?

4 Answers

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answered by JUANA
Pathogenesis:
Low density lipoprotein receptor, also known as Apo B, E receptor, is a cell surface glycoprotein in liver cells was the most and the low density lipoprotein receptor gene located on human chromosome nineteenth, cause familial hypercholesterolemia is the incidence of low density lipoprotein receptor gene natural mutations, including deletion, insertion, no antisense and missense mutations have been found, dozens of low density lipoprotein receptor gene mutations can be divided into five categories.
Type I mutation: the mutant gene does not produce measurable LDL receptor. There is no low density lipoprotein receptor on the cell membrane. It is the most common mutation type.
Type II mutation: the low density lipoprotein receptor synthesized by mutant gene is impaired in cell maturation and transportation, and the low density lipoprotein receptor on the cell membrane is significantly reduced.
Class III mutation: its characteristic is that the low density lipoprotein receptor synthesized by the mutant gene can be found on the surface of the cell, but it can not bind to the ligand.
Class IV mutation: this kind of mutation is a mature low density lipoprotein receptor that can combine low density lipoprotein (LDL) after reaching the cell surface, but it does not appear to be moved.
Class V mutation: its characteristics are low density lipoprotein receptor synthesis, low density lipoprotein binding and subsequent internal migration, but the receptor can not be recirculated to the cell membrane.
Different races, low density lipoprotein receptor mutations are different, such as heterozygous familial hypercholesterolemia in the French-Canadians receptor gene deletion mutations accounted for 60% of the most prominent defects of low density lipoprotein receptor abnormalities were low density lipoprotein from plasma decomposition slows down, in the low density lipoprotein receptor normally, some intermediate density lipoprotein directly by the liver low density lipoprotein receptor uptake and decomposition, while in familial hypercholesterolemia, low density lipoprotein can not be decomposed, resulting in intermediate density lipoprotein more into low density lipoprotein, low density lipoprotein production increased to.
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answered by DIANNA
Blood lipids are mainly composed of cholesterol and triglycerides. Cholesterol is also divided into high-density lipoprotein cholesterol (low cholesterol), low density lipoprotein cholesterol (bad cholesterol) and so on. Hyperlipidemia is a systemic disease, which refers to excessive cholesterol and triglycerides in blood or low high density lipoprotein cholesterol, which is also called hyperlipidemia. There are many reasons causing hyperlipidemia, but to sum up, there are three main reasons: (1) genetic factors, mainly refers to the genetically determined primary hyperlipidemia; (2) secondary to endocrine and metabolic diseases or other diseases, such as obesity, diabetes, thyroid function, reduce nephrotic syndrome and, taking certain drugs; (3) unhealthy lifestyles such as smoking, drinking, lack of exercise, high glucose and high fat diet.
Hyperlipidemia is usually divided into the following four types: hypercholesterolemia: elevated total cholesterol; the high glycerin three greases: triglyceride content increased; the mixed hyperlipidemia: total cholesterol and triglyceride content were increased; the low high-density lipoprotein cholesterol, high density lipoprotein cholesterol.
With the improvement of living standards, the prevalence of hyperlipidemia is increasing, and about every 5 people have a hyperlipidemia. Hyperlipidemia is more obscure. It has almost no specific symptoms. Sometimes it has symptoms of dizziness, fatigue, forgetfulness, insomnia and chest tightness. It is often confused with symptoms of other diseases, and sometimes there are no symptoms. Hyperlipidemia, the greatest harm resulting from this, it destroys your blood vessels and organs imperceptibly. Hyperlipidemia can cause systemic atherosclerosis, leading to coronary atherosclerotic disease such as coronary heart disease, stroke and peripheral vascular diseases, and also can cause fatty liver and acute pancreatitis and other diseases.
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answered by DOREEN
1. the loss of diet. Improper diet, excessive feeding, or greasy food as sweet food, too much grease with food into the body, distribution and transformation time, retention in the blood, and elevated blood lipids. Long term or improper diet, excessive drinking, damage the spleen and stomach, invigorating our loss, resulting in the diet is not reformed, not to become subtle body nutrition, fat turbid, mixed with blood, caused by elevated blood lipids. The former is an empirical study, and the latter is a false positivism, which is the difference between the two.
2. happy and quiet. Or a quiet, sleepy and less dynamic; or because the occupation work limit, sedentary, much less go sit, lost in the body Qi Shu Chang, Qi Qi, body fluid unfavorable. Grease conversion is less than that with less deposition in vivo, steeped in blood, therefore elevated blood lipids.
3. emotional stimulation thinking injured spleen, spleen, or whole liver injury, the failure of the liver, gas poor, lipid transport and transport abnormality, elevated blood lipids.
Aging in 4.. The old man is the viscera are bad, in kidney: kidney deficiency, body fluid loss five liquid. The master; transportation of spleen, spleen deficiency, diet is not reformed; the function of the liver, liver Qi weak body fluid negative, three are the fat metabolic disorder caused by elevated blood lipids. If the house is overworked and the hard work is worried, it can also make the man old and old.
5. physical endowment. After the parents childhood obesity, adult, body fat, more plump, and Yang often lack of body fluid, grease lose of slow, more blood quality education. Or the body of the body Yin deficiency yang hyperactivity, fat into the blood, blood, blood lipids.
6. thirst, edema, hypochondriac pain, jaundice, syndrome and other syndromes are not healed. The basic pathogenesis of diabetes is due to yin deficiency, xuhuo perturbation, gastropyretic polyphagia polydipsia, patients often, but not fat diet and subtle body fat storage, as well as anti melting into paste, mixed with blood, leading to elevated blood lipids. Edema time, damage the spleen and kidney, deficiency of kidney and spleen deficiency can not be the main solution to Jianyun, so that fat metabolism. Hypochondriac pain, jaundice, in plot three of them belong to the liver and gallbladder disease, liver Qi lost to catharsis, effect of grease compresses transformation, bilious not net voiced fat, caused by elevated blood lipids.
The symptoms of high blood lipid. The high blood lipids often have no subjective symptoms and signs of increased blood lipids, if time is longer, the lipid in endothelial deposition caused by atherosclerosis, resulting in dizziness, headache, headache, coronary heart disease, cerebrovascular disease and peripheral vascular disease. There may be corresponding symptoms and signs, very few patients can appear yellow, corneal tumor bow and lipemia fundus changes occurred in the family, but for patients with hyperlipidemia.
Many people are often very nervous and overwhelmed when they are found to have too high blood lipids. They are eager to take some lipid-lowering drugs. The result is not ideal or even side-effects. In fact, hyperlipidemia is a lifestyle disease or a modern civilization disease in a sense. A large number of research results show that the adjustment of lifestyle is the basis for the treatment of hyperlipidemia. The key to the adjustment of life style is to change two aspects of eating habits and moderate exercise.
A proper diet is the first to make a negative balance of heat metabolism. 20-40 year old adults need three thousand calories per day, then each increase of 10 years, respectively, to decrease 5%-30%. The calorie contained in a daily diet should be close to or slightly lower than this standard, while the scientific selection of food types should be paid attention to. Eat less high sugar food and choose vegetable oil rich in unsaturated fatty acids. Dietary cholesterol almost entirely from animal food, the egg, animal brains and visceral cholesterol rich, fried chicken sandwiches and cholesterol are more, should eat or not eat. And some vegetables such as onions, bamboo shoots, and health effects such as fruit grapefruit, jujube, Cili, banana, orange, hawthorn and other types of regulating blood lipid metabolism, delaying arteriosclerosis, often eat a lot of benefits.
There is only a relatively negative way of eating a diet. If you can often take part in physical exercise, the effect of lowering blood fat will be better. Measured, longer aerobic exercise
(such as jogging, long distance walking) is more suitable for reducing blood lipids.
In clinical, hyperemia can be divided into two categories: (1) primary, hereditary metabolic disorder, relatively rare. (2) secondary, common in poor control of diabetes, drinking, hypothyroidism, nephrotic syndrome, biliary obstruction, oral contraceptives, and so on. For the first class, it is generally believed that drug therapy should be used more actively on the basis of adjusting diet and exercise. For the latter category, life style and treatment basis should be the most important. But when the above methods are not significant, doctors should also be guided to use drugs.
The results of modern medical research clearly indicate that changes in physiology and pathology, including the abuse of drugs, cause the change of hormones (such as insulin, thyroxine, adrenocortical hormone, etc.) and the abnormality of metabolism (especially sugar metabolism), which can cause hyperlipidemia.
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answered by MARCELLA
High blood fat is due to the daily non exercise, the intake of oil is too large, working life pressure, and other factors.
Hyperlipidemia refers to the excessive or low cholesterol (TC) and / or triglyceride (TG) or high density lipoprotein cholesterol (HDL-C) in the blood. Modern medicine is called a blood lipid abnormality. Hyperlipidemia is a chronic disease. Most patients do not have symptoms in the early stage of onset. However, no symptoms are not equal to low blood lipids. Regular examination of blood lipids is very important. When the hyperlipidemia develops to a certain level, the patient will suffer dizziness, fatigue, insomnia, forgetfulness, numbness of the limbs, palpitation, chest tightness, palpitation and other symptoms due to insufficient blood supply of the heart and brain.
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