What is the early symptoms of leukaemia?

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asked in Infectious Diseases by MISTY
What is the early symptoms of leukaemia?

3 Answers

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answered by ANTOINETTE
Leukemia is also called leukemia, is one of the ten high incidence of malignant tumors, the incidence of a linear upward trend after the onset of death number. Its etiology is exposure to benzene and its derivatives, contact with radioactive substances, heredity, viral infection and so on. The pathological feature is leukocyte dysplasia in bone marrow and other hematopoietic tissues. The number of leukocytes in abnormal hyperplasia can affect normal hematopoiesis. What is the symptom of leukaemia?
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Early symptoms of leukemia are easily overlooked
The abrupt onset of leukemia, the early symptoms are fever, anemia, joint pain. The disease progresses slowly, the early symptoms are not obvious, and the symptoms are easily ignored. A few patients also have early symptoms such as blindness, gingival swelling and pain, pericardial effusion, and so on. The first symptoms of severe patients include convulsions and paraplegia of the lower extremities.
1. fever
The degree of fever is different, and the cause of the disease is different. The fever is accompanied by oral ulcers, gingival swelling and pain, and perianal abscess, etc. Inflammation of the ear, pyelonephritis and septicemia will occur successively after fever.
2. infection
Pathogens are more common with bacteria and fungal infections. Virus infection is rare, but the virus infection after acute onset, symptoms.
3. haemorrhage
First is the nasal bleeding, then the gingival bleeding, serious skin, digestive tract, respiratory tract bleeding. Excessive menstruation, large amount of bleeding is also the first symptom.
4. anaemia
The early symptoms of anemia, old age, with pale complexion, palpitation, shortness of breath.
5. bone and joint pain
Pain in the limbs, inconvenient walking, and pressure of the sternum are all symptoms of leukaemia. Diffuse pain in the back of some patients is also visible, caused by the infiltrating periosteum of leukaemia.
6. liver and spleen and lymph node enlargement
Splenomegaly is more common, and lymph node enlargement can involve the lymph nodes such as peritoneum and mesentery. The incidence of liver, spleen and lymph node enlargement is high.
7. central nervous system leukemia
Headache, vomiting, coma, intracranial hemorrhage, visual impairment, and facial paralysis are symptoms of the central nervous system in leukemia.
8. other tissues and organs infiltration
Leukaemia infiltrates the uterus, the ovary, the breast, and the corresponding symptoms occur; the leukaemia infiltrates the pleura, the kidney and the brain, and the corresponding symptoms will also appear.
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answered by JEANNETTE
[clinical manifestation]
1, abrupt onset or slow onset of leukemia, children and adolescents with abrupt onset. Common symptoms include fever, progressive anemia, significant bleeding tendency, or bone and joint pain. The slow onset of the disease is the majority of the elderly and some young patients, and the disease progresses gradually. Most of these patients are progressive fatigue, pale, tired, anxious, shortness of breath, loss of appetite, weight loss or fever of unknown origin. In addition, a few patients can be affected by convulsions, blindness, toothache, gingival swelling, pericardial effusion, and paraplegia of the lower extremities.
2, fever and infection
A, fever is one of the most common symptoms of leukemia. It can occur at different stages of the disease and has different degrees of fever and heat. The main reason is infection with fever, angina, stomatitis, perianal inflammatory diseases are most common, pneumonia, tonsillitis, gingivitis, perianal abscess is more common. The ear inflammation, enteritis, carbuncle, pyelonephritis and so on can also be seen, the severe infection can also occur septicaemia, sepsis and so on.
B, infected pathogens are more common in bacteria, and in the early stages of the disease, gram-positive cocci is the main type. Although the virus infection is rare but often more dangerous, the infection of cytomegalovirus, measles or chickenpox is easy to be complicated with pneumonia. It must be paid attention to.
3, bleeding and bleeding is also a common symptom of leukemia. The bleeding site can be covered by the whole body. The most common bleeding is skin, gingiva and nasal cavity, and there are also hemorrhage in the retina, ears, and internal organs, gastrointestinal tract and respiratory tract. Female menorrhagia is also more common and is the first symptom. The M3 and M5 subtypes of AML are more severe, especially in M3 patients, which are prone to diffuse intravascular coagulation (DIC) and intracranial hemorrhage.
4, anemia can occur early, a small number of cases of refractory anemia diagnosed in the first few months or years after developed leukemia. Patients often have symptoms such as fatigue, paleness of face, palpitation, shortness of breath, swelling of the lower limbs and so on. Anemia is seen in all types of leukemia, but more of the elderly AML patients, many patients often with anemia as the first symptom.
5. Infiltration of leukemic cells
A, liver, splenomegaly, lymphadenopathy
B, nervous system: major lesions are bleeding and leukaemia infiltration
C, bone and joint: bone and joint pain is one of the most important symptoms of leukemia, and ALL is common.
D, skin; can have specific and nonspecific skin lesions in two, the former is maculopapule, pustules, nodules, lumps, erythroderma, exfoliative dermatitis, more common in adult monocytic leukemia, the latter showed skin ecchymosis, spots etc..
E, oral cavity: gingival swelling, bleeding, leukemic infiltration is more common in AML-M5. Severe patients can be extremely hyperplastic, swelling like sea sponge, and burst on the surface.
F, heart: most of them are infiltration of myocardial leukemia, bleeding and epicardial hemorrhage, pericardial effusion, etc.
G, kidney: leukaemia with renal lesions up to 40%.
H, gastrointestinal system: nausea and vomiting, lack of appetite, abdominal distention, diarrhea, etc.
I, lung and pleura: it mainly infiltrates the alveolar wall and the pulmonary space, and also can infiltrate the bronchus, pleura, and the wall of the blood vessels.
J, the other: uterus, ovary, testis, prostate and so on can be infiltrated by white blood cells. Female patients often have vaginal bleeding and menstrual cycle disorders. A male patient may have a loss of sexual desire.
[diagnostic criteria]
1, the clinical symptoms of sudden high fever, anemia or significant bleeding, aches and pain fatigue.
2, signs of skin bleeding spots, sternal tenderness, hepatosplenomegaly, lymph node.
3. Laboratory:
A, hemogram leucocyte always obviously increase (or decrease), can appear primitive or naive cells.
B, bone marrow bone marrow nucleated red blood cells of total nucleated cells below 50%, the original cell is more than 30%, can be diagnosed as acute leukemia; bone marrow nucleated red blood cells is more than 50%, the original non erythroid cells accounted for the proportion of more than 30%, can be diagnosed as acute leukemia.
Differential diagnosis:
A, aplastic anemia;
B, myelodysplastic syndrome;
C, malignant histiocytic disease;
D, idiopathic thrombocytopenic purpura
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answered by BEULAH
Early symptoms of leukemia
The early symptoms of leukemia is more, most patients with fever as early manifestations of fever 38 degrees below 39 degrees above also have high fever. Most of the heat is not the rule, often accompanied by nasal congestion, runny nose, cough and other respiratory tract infections, cold symptoms or urinary urgency and other symptoms of urinary tract infection, poor. These symptoms are misdiagnosed at many times, and a large number of abnormal cells are leukemia patients if they are checked out of the peripheral blood of the patient. Headache, nausea, vomiting and other symptoms are easy to be misdiagnosed, in addition to paralysis, delirious symptoms.
Anemia, in addition to fever, is the most common starting symptom. The main manifestations were pale, weakness, sweating, often feel shortness of breath, heartbeat. And the situation is getting worse. But there are many reasons for anemia, and it is necessary to distinguish the anemia caused by other reasons.
Most of the leukemia patients had enlarged superficial lymph nodes, mainly in the submandibular, neck, supraclavicular, axillary and inguinal regions. When will the sternum hepatosplenomegaly has apparent tenderness, it has been said that a large number of leukemia cells in the marrow.
Haemorrhage is one of the most obvious symptoms of leukemia. May occur in patients with unexplained skin ecchymosis, oral and nasal cavity, gingival bleeding, menorrhagia, bleeding. Patients with fundus bleeding may have blurred symptoms of the retina; patients with intracranial hemorrhage have severe headaches during nausea and vomiting. Therefore, when the above situation occurs, we should go to the hospital in time.
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